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British journal of cancer · Apr 1981
Randomized Controlled Trial Clinical TrialA randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
- N M Bleehen, C R Wiltshire, P N Plowman, J V Watson, J R Gleave, A E Holmes, W S Lewin, C S Treip, and T D Hawkins.
- Br. J. Cancer. 1981 Apr 1; 43 (4): 436-42.
AbstractThe results are reported of a small clinical trial carried out to assess the potential value of the hypoxic cell radiosensitizer misonidazole in the radiation treatment of Grade 3 and 4 supratentorial astrocytomas. A total of 55 patients were randomly allocated to one of 3 treatment groups. No significant differences were seen between the median survivals of patients in the 2 control radiation groups and that of the third group in which oral misonidazole at a dose of 3 g/m2 preceded each of 4 weekly radiation doses. Possible reasons why no improvement was seen are discussed in detail.
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