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- Samuel Rosner, Joshua E Reuss, and Patrick M Forde.
- Upper Aerodigestive Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA; email: srosner3@jhmi.edu , jreuss1@jhmi.edu , pforde1@jhmi.edu.
- Annu. Rev. Med. 2019 Jan 27; 70: 425-435.
AbstractEarly-stage non-small cell lung cancer is a potentially curable disease, but with relapse rates exceeding 50% with standard treatments, this is a patient population in critical need of therapy innovation. Immunotherapy with immune checkpoint blockade has revolutionized the treatment strategy for advanced lung cancer. However, the role of this therapy in earlier-stage disease is largely unknown. The study of immunotherapy in earlier-stage disease has many advantages, including assessment of pathologic response and incorporation of translational scientific analyses to evaluate antitumor immune responses. Multiple clinical trials are currently under way, with promising early results.
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