• Ran Lee, Hye-Ran Ahn, Min-Ho Shin, Hee-Nam Kim, Young-Hoon Lee, Seong-Woo Choi, and Sun-Seog Kweon.
• Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea.
• J. Korean Med. Sci. 2018 Jun 4; 33 (23): e165e165.

BackgroundWe investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population.MethodsWe selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD.ResultsPTX3 was inversely associated with the BMD of the lumbar spine (P = 0.010) and femoral neck (P < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (P = 0.020).ConclusionThis study suggests that PTX3 levels might be inversely associated with BMD in elderly men.

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