• M G Betjes, J Weening, and R T Krediet.
• Department of Internal Medicine, Division of Nephrology and Hypertension, University Hospital Rotterdam-AZR, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
• Neth J Med. 2001 Sep 1; 59 (3): 111-7.

AbstractHuman immunodeficiency virus-associated nephropathy (HIVAN) is a distinct clinico-pathological syndrome that occurs almost exclusively in black patients with an AIDS defining diagnosis. It is characterized by rapidly progressive renal failure with a severe nephrotic syndrome. The renal biopsy typically shows a collapsing glomerular sclerosis and variable tubulo-interstitial nephritis. The pathogenesis most likely involves infection of renal tubular and epithelial cells with HIV. The use of ACE-inhibitors and steroids may slow down the progression to end-stage renal failure. With the introduction of highly active anti-retroviral therapy, HIVAN may now be treated effectively although clinical data are so far limited to case-reports.

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