• Alexander Stojadinovic, Eric Elster, Benjamin K Potter, Thomas A Davis, Doug K Tadaki, Trevor S Brown, Stephen Ahlers, Christopher E Attinger, Romney C Andersen, David Burris, Jose Centeno, Hunter Champion, David R Crumbley, John Denobile, Michael Duga, James R Dunne, John Eberhardt, William J Ennis, Jonathan A Forsberg, Jason Hawksworth, Thomas S Helling, Gerald S Lazarus, Stephen M Milner, Florabel G Mullick, Christopher R Owner, Paul F Pasquina, Chirag R Patel, George E Peoples, Aviram Nissan, Michael Ring, Glenn D Sandberg, Wolfgang Schaden, Gregory S Schultz, Tom Scofield, Scott B Shawen, Forest R Sheppard, James P Stannard, Peter J Weina, and Jonathan M Zenilman.
• Walter Reed Army Medical Center, Department of Surgery, 6900 Georgia Avenue NW, Washington, DC 20307, USA.
• Mil Med. 2010 Jul 1; 175 (7 Suppl): 18-24.

AbstractThe Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.

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