• Neth J Med · Nov 2016

    Case Reports

    An impressive response to pazopanib in a patient with metastatic endometrial carcinoma.

    • M J van der Steen, Y R P de Waal, A Westermann, B Tops, W Leenders, and P B Ottevanger.
    • First auteur: Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands Second auteur: Gynaecological Oncology, Amsterdam Medical Centre, Amsterdam, the Netherlands.
    • Neth J Med. 2016 Nov 1; 74 (9): 410-413.

    AbstractThe incidence of endometrial carcinoma is rising and the patients with distant metastases have a poor prognosis, especially when progression of disease occurs after systemic treatment with hormonal therapy or chemotherapy. Pazopanib, a multi-targeted inhibitor of several oncogenic receptor tyrosine kinases, has been investigated in patients with chemotherapy-resistant endometrial carcinoma or patients for whom chemotherapy is contraindicated. In this report we will describe a spectacular response to pazopanib in a patient with recurrent metastatic endometrial carcinoma.

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