• Presse Med · Nov 2005

    Review

    [FGF23, a "new" hormone regulating phosphate homeostasis and vitamin D metabolism].

    • C Silve.
    • Inserm U 683, Faculté de médecine Xavier Bichat, 75018 Paris. silve@bichat.inserm.fr
    • Presse Med. 2005 Nov 5; 34 (19 Pt 1): 1384-90.

    AbstractUntil recently, the action of two hormones - parathyroid hormone (PTH) and calcitriol - on three target tissues - bone, kidney, and gut - has been thought to regulate the closely linked homeostasis of calcium and phosphates. In this system, an increase in the plasma concentration of one ion often leads to a reciprocal change in the concentration of the other and PTH stimulates 1 alpha-hydroxylase activity and calcitriol synthesis in renal proximal tubular cells. A second phosphate regulation system was recently identified. It involves one or more phosphaturic hormones, called "phosphatonins", that is, circulating factors with potent phosphaturic activity. The key phosphatonin appears to be a fibroblast growth factor, known as FGF23. It is now established that FGF23 regulates not only phosphate homeostasis, but also vitamin D metabolism. In contrast to PTH, however, FGF23 inhibits rather than stimulates 1 alpha-hydroxylase activity and calcitriol synthesis.

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