• Yonsei medical journal · Apr 2009

    Microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in Korean trios.

    • Hanik K Yoo, Seockhoon Chung, Jin Pyo Hong, Boong-Nyun Kim, and Soo Churl Cho.
    • Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
    • Yonsei Med. J. 2009 Apr 30; 50 (2): 304306304-6.

    AbstractThis study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit beta3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 +/- 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 +/- 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.

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