• Presse Med · Nov 2011

    Review

    [Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].

    • Stéphane Burtey.
    • Hôpital de la conception, centre de néphrologie et transplantation rénale, 13005 Marseille, France. stephaneb@ap-hm.fr
    • Presse Med. 2011 Nov 1; 40 (11): 1059-64.

    AbstractAutosomal dominant polycystic kidney disease is the most frequent renal genetic disease. Its main complication is renal failure. Despite a better understanding of the mechanisms leading to cyst development and growth, no specific treatment is available. Inhibition of mTOR pathway was a great hope, unfortunately, two clinical trials failed to show a clinical benefit. Numerous new drugs are in clinical trials or in the pipe-line. We could hope, in the 5 years to the emergence of an efficient treatment to slow the pace of renal failure in ADPKD.Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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