• Jongkeun Park, Kijun Song, Yangsoo Jang, and Kim YoonSungjooSDepartment of Medical Life Science, The Catholic University of Korea, Seoul, Korea. sjkyoon@catholic.ac.kr..
• Department of Medical Life Science, The Catholic University of Korea, Seoul, Korea.
• Yonsei Med. J. 2015 Jan 1; 56 (1): 227234227-34.

PurposeThe aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans.Materials And MethodsTo outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects.ResultsLogistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069-2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in postmenopausal HT women (p=0.003 and p=0.017, respectively). Analysis of the promoter containing rs6682082 revealed a 2.4±0.01-fold higher activity in the A variant promoter than the G variant promoter, suggesting that rs6682082 is itself a functional variant.ConclusionWe suggest that the A allele of rs6682082 is a positive genetic marker for predisposition to essential hypertension and high BP in Korean women and may be mediated through the transcriptional activation of REN.

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