• Tank Ocak, Arif Duran, Gülzade Özyalvaçli, Zeynep Ocak, Elçin Hakan Terzi, Mehmet Tosuns, and Kemalettin Erdem.
• Department of Emergency Medicine, Abant İzzet Baysal University, Bolu, Turkey. tarikocak78@gmail.com
• Turk J Med Sci. 2014 Jan 1; 44 (3): 381-6.

AimTo evaluate the effects of montelukast and Hypericum perforatum against ischemia/reperfusion (I/R)-induced intestinal damage.Materials And MethodsTwenty-eight hamsters were divided into 4 groups following midline abdominal laparotomy: control group (n = 7), I/R group (n = 7), montelukast and I/R (MIR) group (n = 7), and Hypericum perforatum and I/R (HPIR) group (n = 7). After 60 min of ischemia through obstruction of the superior mesenteric artery, 24 h of reperfusion was maintained. Ten minutes prior to the reperfusion period, the MIR group received 7 mg/kg of intraperitoneal montelukast and the HPIR group received 7 mg/kg of intraperitoneal Hypericum perforatum. Malondialdehyde, glutathione, myeloperoxidase, and cardiotrophin-1 levels were measured from blood samples. A semiquantitative histological evaluation was performed.ResultsMontelukast and Hypericum perforatum significantly reduced malondialdehyde levels and increased glutathione levels compared to the I/R group (P < 0.008). A statistically significant difference was also found between the I/R group and MIR and HPIR groups in terms of myelqperoxidase levels (P < 0.008). The MIR and HPIR groups showed increased cardiotrophin- 1 levels compared to the control and I/R groups (P < 0.008 for all). The MIR and HPIR groups showed significantly lower histological scores compared to the I/R group (P = 0.03 and P = 0.007, respectively).ConclusionThis study demonstrated the preventive effects of montelukast and Hypericum perforatum on I/R-induced intestinal injury.

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