• Kwangha Lee, Youjin Chang, Kyuyoung Song, Yun Young Park, Jin Won Huh, Sang Bum Hong, Chae Man Lim, and Younsuck Koh.
• Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
• Yonsei Med. J. 2016 Jan 1; 57 (1): 111117111-7.

PurposeHigh mobility group box 1 (HMGB1) plays a central role in the pathogenesis of sepsis and multiple organ dysfunction syndromes. We investigated the associations of a single nucleotide polymorphism (SNP; rs1045411) in HMGB1 with various clinical parameters, severity, and prognosis in patients with sepsis, severe sepsis, or septic shock.Materials And MethodsWe enrolled 212 adult patients followed for 28 days. All patients were genotyped for rs1045411, and the serum levels of HMGB1 and several cytokines were measured.ResultsThe proportions of patients according to genotype were GG (71.2%), GA (26.4%), and AA (2.4%). Among patients with chronic lung disease comorbidity, patients with a variant A allele had higher positive blood culture rates and higher levels of various cytokines [interleukin (IL)-1β, IL-6, IL-10, IL-17, and tumor necrosis factor-α] than those with the GG genotype. In the analysis of those with diabetes as a comorbidity, patients with a variant A allele had higher blood culture and Gram-negative culture rates than those with GG genotypes; these patients also had a higher levels of IL-17. In the analysis of those with sepsis caused by a respiratory tract infection, patients with a variant A allele had higher levels of IL-10 and IL-17 (all p<0.05). This polymorphism had no significant impact on patient survival.ConclusionThe variant A allele of rs1045411 appears to be associated with a more severe inflammatory response than the GG genotype under specific conditions.

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