High-dose epidural fentanyl does not slow gastric emptying in labouring women compared to low-dose fentanyl.

pearl

• Elisheva Fiszer, Boris Aptekman, Yuval Baar, and Carolyn F Weiniger.
• From the Department of Anaesthesia, Intensive Care and Pain, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (EF, BA, YB, CFW).
• Eur J Anaesthesiol. 2022 Jan 1; 39 (1): 505750-57.

BackgroundEpidural fentanyl doses above 100 μg have been shown, using the paracetamol absorption test, to reduce gastric emptying in fasted labouring women.ObjectiveTo investigate the effect of fentanyl dose on gastric emptying in nonfasted labouring women using gastric ultrasonography.DesignA double-blinded randomised controlled study.SettingA tertiary medical centre in Tel Aviv, Israel between 30 July 2020 and 11 October 2020.PatientsEighty labouring women with cervical dilation 5 cm or less, at least 18 years age, at least 37 weeks gestation with a singleton pregnancy and cephalad foetus.InterventionsWomen randomised to high (>100 μg) or low (<100 μg) cumulative epidural fentanyl had ultrasound gastric content assessment, measuring antral cross-sectional area (CSA) at epidural placement and 2 h thereafter (T2  h).Main Outcome MeasuresThe primary outcome was CSA at T2  h comparing high-dose versus low-dose fentanyl. Secondary outcomes included change in CSA between baseline and T2  h. Sub-group analysis compared stomach content at T2  h according to baseline stomach content, empty (CSA <381 mm2) or full (CSA ≥381 mm2), and high-dose versus low-dose fentanyl.ResultsData from 80 women were analysed; 63 had empty and 17 had full stomach at baseline. There was no significant difference in CSA at T2  h between high-dose, mean 335 ± SD 133 mm2, versus low-dose fentanyl, mean 335 ± SD 172 mm2, P = 0.991. Change in CSA baseline to T2  h was 46 ± SD 149 mm2 for high and 49 ± SD 163 mm2 for low-dose group, P = 0.931. The subgroup analysis according to baseline stomach content showed no statistically significant differences in CSA at T2  h.ConclusionThe CSA at T2  h was similar for women who received high-dose versus low-dose epidural fentanyl, measured by ultrasound, in our nonfasted labouring cohort.Trial RegistrationClinicaltrials.gov number: NCT04202887.Copyright © 2021 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

14 keywords...

hide…