• Haidong Fu, Jianhua Mao, Yanping Xu, Weizhong Gu, Xiujuan Zhu, and Aimin Liu.
• The Children's Hospital of Zhejiang University School of Medicine, Department of Nephrology, Hangzhou 310003, China.
• Clinics (Sao Paulo). 2016 Sep 1; 71 (9): 550-4.

ObjectiveTo investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment.MethodsEleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN).ResultsDEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN. IgA, IgG and IgM antibody deposition was found in DEP-HSPN by histopathological examination. Proteinuria cleared in all 11 cases through treatment with steroids and/or immunosuppressive drugs. However, half of the DEP-HSPN patients continuously had hematuria after treatment.ConclusionThe early diagnosis and prompt initiation of immunosuppressive treatment based on renal biopsy are important for achieving favorable outcomes.

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