• Am. J. Med. · Feb 2017

    Review

    Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Brief Overview.

    • Zachary R Noel and Craig J Beavers.
    • PPS Department, University of Maryland College of Pharmacy, Pharmacy Hall, Baltimore.
    • Am. J. Med. 2017 Feb 1; 130 (2): 229.e1-229.e4.

    AbstractProprotein convertase subtilisin/kexin type 9 inhibitors serve as a valuable addition to the armamentarium of lipid-lowering agents and have promising potential. By inhibiting the proprotein convertase subtilisin/kexin type 9 enzyme, this novel molecule leads to increased low-density lipoprotein receptor density and decreased circulation of low-density lipoprotein. The fact the agent is a monoclonal antibody has led to limited drug interactions and minimized adverse drug events. It is critical for all providers to have a basic understanding of these novel therapies with their introduction and use for treatment.Copyright © 2016 Elsevier Inc. All rights reserved.

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