• Wien. Klin. Wochenschr. · Oct 2017

    Comparative Study

    Association between high cytomegalovirus antibody titers and blood pressure in the adult Kazakh and Han Chinese populations.

    • Na Tang, Jia-Wei Li, Yong-Min Liu, Hua Zhong, La-Mei Wang, Feng-Mei Deng, Jing Hui, Yuan-Yuan Qu, and Fang He.
    • Department of Pathophysiology/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, 832002, Shihezi, China.
    • Wien. Klin. Wochenschr. 2017 Oct 1; 129 (19-20): 709716709-716.

    BackgroundHuman cytomegalovirus (CMV) has been linked to the pathogenesis of elevated arterial blood pressure (BP). Our study aimed to determine the association between anti-CMV titers and arterial BP in the Kazakh and Han Chinese populations.Material And MethodsKazakh and Han (n = 800 each) (age, ≥18 years) subjects from Xinjiang, China were examined for anti-CMV immunoglobulin (Ig)G titers using a commercially available enzyme-linked immunosorbent assay (ELISA) kit. The highest anti-CMV titer tertiles determined within gender and ethnicity groups were compared against the two lower tertiles and seronegative samples.ResultsMultivariate linear regression analysis revealed that anti-CMV titers were independent determinants for elevated systolic (p = 0.006) BP in Kazakh women and inversely associated with systolic (p = 0.004) and mean arterial (p = 0.019) BP in Han women.ConclusionThe association between CMV infection and/or resulting immune response and BP elevation differed by sex and ethnicity. In Kazakh women, they were associated with elevated BP and the opposite was true among Han women.

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