• Internal medicine journal · Oct 2010

    Case Reports

    Reversible posterior leukoencephalopathy syndrome: diagnosis and management in the setting of lung transplantation.

    • B K T Tsang, F D Kermeen, P M A Hopkins, and D C Chambers.
    • Queensland Centre for Pulmonary Transplantation and Vascular Disease, the Prince Charles Hospital, Brisbane, Queensland, Australia. Benjamin_tsang@health.qld.gov.au
    • Intern Med J. 2010 Oct 1; 40 (10): 716-20.

    AbstractReversible posterior leukoencephalopathy syndrome (RPLS) is a potentially devastating early complication of calcineurin inhibitor (CNI) therapy in solid organ transplantation. Management centres on cessation of CNI therapy; however, this strategy is complicated in lung transplantation because of the threat of allograft rejection, or, if CNI is replaced with mammalian target of rapamycin-based immunosuppression, poor wound healing and bronchial dehiscence. We describe four cases of RPLS after lung transplantation, emphasizing the diagnostic and management approach required to maintain a healthy allograft and ensure that RPLS is, as the name suggests, reversible.

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