• Chin-Hsiao Tseng.
• Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan. ccktsh@ms6.hinet.net
• Ann. Med. 2011 Mar 1; 43 (2): 142150142-50.

BackgroundTo evaluate the trend of prostate cancer mortality in Taiwanese general population and the association between diabetes and prostate cancer mortality.Materials And MethodsIn the general population during 1995-2006, the trends of prostate cancer mortality were evaluated, followed by calculation of age-specific mortality rates for age 40-64, 65-74, and ≥ 75 years. A cohort of 102,651 diabetic men aged ≥ 40 years recruited in 1995-1998 was followed prospectively.ResultsThe trends of crude and age-standardized mortality from prostate cancer in the general population increased significantly (P < 0.0001). In the general population, 7,966 men aged ≥ 40 years died of prostate cancer, and aging was associated with increased risk. Age-specific prostate cancer mortality suggested significantly increasing trend for ages 65-74 and ≥ 75 years. A total of 321 diabetic men died of prostate cancer (crude mortality rate 41.9/100,000 person-years). Mortality rate ratios (95% confidence interval) showed higher risk of prostate cancer mortality in the diabetic patients, with magnitude increased with decreasing age: 1.55 (1.29-1.86), 2.68 (2.29-3.13), and 6.84 (5.34-8.75) for age ≥ 75, 65-74, and 40-64 years, respectively.ConclusionsProstate cancer mortality in the Taiwanese general population is increasing. Diabetic patients have a higher risk of prostate cancer mortality, which is more remarkable with decreasing age.

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