• Min Yuan, Weiping Chen, Huangyan Zhou, Zhilong Xiao, Wei Wang, Weidong Wang, Xiaoping Yin, and Lijun Xu.
• Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
• Med Princ Pract. 2016 Jan 1; 25 (3): 286289286-9.

ObjectiveThe aim of this paper was to report the first case of Kennedy disease misdiagnosed as polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome.Clinical Presentation And InterventionA 58-year-old Chinese man presented with limb numbness, progressive limb proximal weakness, lymph node and thyroid enlargement, edema, pigmentation in the lower limb, and obvious gynecomastia, which was initially diagnosed as POEMS syndrome and was treated with dexamethasone and small doses of cyclophosphamide without any improvement after 6 months. Finally, the patient diagnosis was confirmed as Kennedy disease (KD) by gene analysis.ConclusionThis case suggests that clinicians should pay more attention to the differential diagnosis between KD and POEMS syndrome. Gene analysis was helpful in detecting this rare confusing disease in this patient.© 2015 S. Karger AG, Basel.

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