• Yuan Yuan, Ming Liu, WenHong Liu, and Hua Du.
• Gansu University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2019 Nov 1; 98 (44): e17643.

BackgroundCurrent research has proved that psoriasis is associated with serum uric acid (SUAC) levels. Our purpose is to clarify SUAC levels and the incidence of hyperuricemia in psoriasis patients, and to compare SUCA levels in different groups' psoriasis patients.MethodsWe plan to search 7 electronic bibliographic databases (PubMed, Embase, Cochrane, and 4 Chinese databases) from inception to August 2019. Literatures selection and data collection will be performed independently by 2 authors. The Newcastle-Ottawa scale will be used to assess the methodologic quality and bias of included studies. Firstly, standard pairwise meta-analysis will be used to examine the considered data synthesis. Secondly, if the identified studies appear sufficiently similar within and across the different comparisons between different groups of psoriasis patients, we will estimate SUAC levels using network meta-analysis in different age and ethnicity psoriasis patients. Mean difference, risk ratio, and 95% confidence intervals will be used to assess the SUAC levels and the incidence of hyperuricemia in psoriasis patients. The software of Stata and WinBUGS will be used to calculations.ResultsThe results will be published in a peer-reviewed journal.ConclusionOur study will compare SUCA levels in different groups' psoriasis patients through network meta-analysis, and we believe our job is very meaningful.Ethics And DisseminationOur study is a secondary study of the existing literature. So, ethical and dissemination approval is not required.

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