• Yang Xu, Guotao Liu, Yv Zhou, Zengzhen Lu, Zhaorui Shi, and Jun Wang.
• Department of Endocrinology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
• Medicine (Baltimore). 2020 Mar 1; 99 (13): e19482e19482.

BackgroundInsulin dependent diabetes mellitus (IDDM) is a kind of heterogeneous disease caused by the interaction of polygene inheritance and environmental factors. The LMP2 and LMP7 are 2 loci in LMP gene, and although genetic association between LMP2 and LMP7 polymorphisms were reported, the results are inconclusive. The aim of this study was to investigate the association between LMP2 and LMP7 polymorphisms and IDDM risk.MethodsAn exhaustive search was performed out through the electronic databases including PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength association between LMP2 CfoI and LMP7 G37360T polymorphisms and IDDM risk.ResultsA total of 7 studies with 707 cases and 821 controls were included in the present study. The results indicated that the dominant model of LMP2 CfoI was significantly associated with IDDM in Asian population (OR = 1.96, 95% CI: 1.24-3.10, P = .004). In addition, the allelic and dominant models of LMP7 G37360T were associated with IDDM in Caucasian population (allelic model: OR = 0.69, 95% CI: 0.56-0.85, P = .0005; dominant model: OR = 0.67, 95% CI: 0.50-0.89, P = .007).ConclusionsThe dominant model of LMP2 CfoI might be a risk factor for IDDM in Asian population. Whereas, the allelic and dominant models of LMP7 G37360T might be protective factors for IDDM in Caucasian population.

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