• Feifei Li, Shuqi Wang, Youlong Yao, Xueming Sun, Xiaoyan Wang, Ning Wang, Yulin You, and Yanli Zhang.
• School of Pharmaceutical Sciences, Shandong University, Jinan, China.
• Medicine (Baltimore). 2021 Nov 5; 100 (44): e27466e27466.

BackgroundMonocarboxylate transports (MCTs), a family of solute carrier protein, play an important role in maintenance of cellular stability in tumor cells by mediating lactate exchange across membranes. The objective of this paper is to evaluate the knowledge structure, development trend, and research hotspot of MCTs research field systematically and comprehensively.MethodsBased on the 1526 publications from 2010 to 2020 retrieved from "Web of Science Core Collection" (WoSCC), we visually analyzed the MCTs research in terms of subject category, scientific collaboration network, keywords, and high-frequency literature using CiteSpace.ResultsThe number of publications exhibits an upward trend from 2010 to 2020 and the top 5 countries in the MCTs research were the United States, China, Japan, Germany, and England. Visser TJ was the most prolific author, while Halestrap AP was the most influential author with the highest citations. Analysis of the 7 cluster units from the co-cited references and keywords revealed that high expression of MCTs induced by oxidative stress and glycolysis was the pivotal point in the MCTs research field, while regulation of metabolism in tumor microenvironment, prognostic markers of cancer, and targeted inhibitors are the top 3 research frontiers topics.ConclusionThis study will help the new researcher to understand the MCTs related field, master the research frontier, and obtain valuable scientific information, thus providing directions for follow-up research.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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