• Fedele Dono, Bruna Nucera, Jacopo Lanzone, Giacomo Evangelista, Fabrizio Rinaldi, Rino Speranza, Serena Troisi, Lorenzo Tinti, Mirella Russo, Martina Di Pietro, Marco Onofrj, Laura Bonanni, Giovanni Assenza, Catello Vollono, Francesca Anzellotti, and Francesco Brigo.
• Department of Neuroscience, Imaging and Clinical Science, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
• Epilepsy Behav. 2021 May 1; 118: 107887.

PurposeIn March 2020, the World Health Organization declared the SARS-CoV-2 infection-related coronavirus Disease (COVID-19) a pandemic. During the first and second waves of the pandemic spread, there have been several reports of COVID-19-associated neurological manifestations, including acute seizures and status epilepticus (SE). In this systematic review, we summarized the available data on clinical features, diagnosis, and therapy of COVID-19-related SE.MethodsWe performed a systematic search of the literature to identify data on demographics, clinical, neurophysiological, and neuroradiological data of patients with COVID-19-related SE. We used regression models (linear or logistic) with a stepwise forward method to identify features associated with mortality or severity of SE.ResultsThirty-nine articles were included with a total of 47 cases of SE associated with COVID-19. Age, time between the acute respiratory phase of SARS-CoV-2 infection and SE onset, and hospitalization correlated with a higher SE severity as assessed by quantitative validated scales.ConclusionsSE can be a neurological manifestation of SARS-CoV-2 infection. Although a possible association between SE and COVID-19 has been reported, the exact mechanisms are still not fully understood. Systemic inflammatory syndrome due to cytokine release could play a role in COVID-19-related SE.Copyright © 2021 Elsevier Inc. All rights reserved.

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