• Swiss medical weekly · Oct 1976

    [The immunologic status during pulmonry tubercuolsis].

    • A Genoud, J J Farquet, E Arnold, J P Girard, and A Cruchaud.
    • Swiss Med Wkly. 1976 Oct 2; 106 (40): 1362-3.

    AbstractThe cellular and humoral immunity of patients with pulmonary tuberculosis has been evaluated prospectively in 22 PPD-positive and 10 PPD-negative patients by intradermoreaction (IDR), blast transformation (SL) and MIF production in response to PPD, Candida and varidase, peripheral lymphocyte count, and quantitative evaluation of immunoglobulins. There is a very good correlation between the different tests, and anergy is frequently found in elderly patients. Negative results (IDR, SL, MIF) are significantly observed in the presence of a negative PPD-IDR, lymphopenia (less than 1,000/mm3), impaired blast transformation in response to PHA (less than 21,000 cpm), and a cavitary form of tuberculosis. These findings suggest a defect of cellular immunity in these patients.

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