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Swiss medical weekly · Sep 1979
[Immunosuppression, bone marrow infusion and low dose androgens, successful therapy of severe aplastic anemia].
- P Cornu, B Speck, A Gratwohl, C Nissen, J Sartorius, and M Jeannet.
- Swiss Med Wkly. 1979 Sep 29; 109 (37): 1384-5.
Abstract18 patients with severe aplastic anemia (SAA) but without an HLA-identical sibling were treated by antilymphocyte globulin (ALG) followed by infusion of marrow cells from a semi-compatible family donor. 13 of these received low dose androgens after ALG: 11 (85%) achieved stable remission without transfusion requirement. One patient relapsed after 4 months, one patient with only partial remission died from infection. None of the 4 patients who did not receive androgens after ALG achieved remission. ALG, marrow and low-dose androgens represent a promising therapy for SAA and can be favorably compared with allogeneic bone marrow transplantation.
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