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Swiss medical weekly · Nov 1998
Case Reports[A patient with rapidly progressing renal failure, florid syphilis and positive HIV serology].
- H R Räz, V Nickeleit, M J Mihatsch, and A Colombi.
- Abteilung für Nephrologie, Kantonsspital Luzern.
- Swiss Med Wkly. 1998 Nov 21; 128 (47): 1850-6.
AbstractWe describe the frist reported case in Switzerland of HIV-associated nephropathy (HIVAN). HIVAN shows a typical combination of clinical findings: black race, proteinuria, large hyper-echogenic kidneys, normal blood pressure, positive HIV serology and no autoantibodies. The histologic findings are typical: focal segmental glomerulosclerosis of the collapsing variant, often with marked interstitial nephritis. The disease normally appears before AIDS symptoms develop and follows a very aggressive course to end-stage renal disease. Therapy consists of a combination of nucleoside reverse transcriptase and proteinase inhibitors, ACE inhibitors, and possibly steroids. In end-stage renal disease patients can be managed by haemodialysis, continuous ambulatory peritoneal dialysis (CAPD) or kidney transplantation.
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