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Swiss medical weekly · Nov 2000
Case Reports[Neonatal alloimmune thrombocytopenia due to a rare anti-HPA-1b antibody].
- P Moosmann, J C Fauchère, J Halter, D Binder, and U Schanz.
- Abteilung für Hämatologie, Transfusionsmedizin, Universitätsspital Zürich.
- Swiss Med Wkly. 2000 Nov 11; 130 (45): 1734-7.
AbstractFoetal and neonatal alloimmune thrombocytopenia is caused by transplacental transfer of antibodies directed against platelet antigens and affects approximately 1 in 1000-2500 neonates. Clinically relevant complications are the intracranial haemorrhages that occur in 10-20% of cases. 20 platelet antigen systems are currently known. However, immunisation is most frequently seen against two of these (HPA-1a and HPA-5b). Treatment options include transfusion of compatible or, if these are not available while urgently needed, random donor platelets, intravenous immunoglobulin, and steroids. We report on a case of neonatal alloimmune thrombocytopenia due to an anti-HPA-1b antibody in the third pregnancy of a 31-year-old Caucasoid woman. The infant was treated with repeated maternal and random donor platelet transfusions and with a single dose of intravenous immunoglobulin.
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