• Crit Care Explor · May 2021

    Oral Midodrine Administration During the First 24 Hours of Sepsis to Reduce the Need of Vasoactive Agents: Placebo-Controlled Feasibility Clinical Trial.

    • Amos Lal, Vrinda Trivedi, Mahrukh S Rizvi, Amy Amsbaugh, Melissa K Myers, Khaled Saleh, Rahul Kashyap, and Ognjen Gajic.
    • Department of Medicine, Division of Pulmonary and Critical Care Medicine, Multidisciplinary Epidemiology and Translational Research in Intensive Care Group (METRIC), Mayo Clinic, Rochester, MN.
    • Crit Care Explor. 2021 May 1; 3 (5): e0382.

    AbstractOur preliminary data and observational studies suggested an increasing "off label" use of oral midodrine as a vasopressor sparing agent in various groups of critically ill patients, including those with sepsis. We designed this clinical trial to evaluate the feasibility of use of midodrine hydrochloride in early sepsis to reduce the duration for IV vasopressors and decrease ICU and hospital length of stay.Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.

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