• Melvin Khee-Shing Leow.
• Clinical Investigator, Singapore Institute for Clinical Sciences, ASTAR; Deputy Director, Clinical Nutrition Research Centre (CNRC), Singapore; Senior Consultant Endocrinologist, Tan Tock Seng Hospital; Clinician Scientist, National Healthcare Group (NHG); Clinical Associate Professor, National University of Singapore; Adjunct Associate Professor, Duke-NUS Graduate Medical School, Singapore; Associate Professor, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
• Int J Med Sci. 2017 Jan 1; 14 (7): 639647639-647.

AbstractBackground: Modern medicine recognizes that salient, inherent variations between Caucasians and Asians exist. Radical changes are occurring in the health scene with increasing emphasis centered on the recognition of inter-individual variations unique to Asians that impact on medical management and outcomes. Aim: This review analyzes distinct features or outcomes in terms of epidemiology, disease thresholds, diagnostic cutoffs and treatment responses of Asian people compared with non-Asians. Methods: This review is based on a literature search via PubMed and MEDLINE for relevant articles related to the Asian phenotype and its impact on health and disease. Results: An 'Asian phenotype' could be characterized across the spectrum of biomedical disciplines and underscores the major challenges clinicians must face in their daily management of a cosmopolitan population and their extrapolation of research outcomes. Conclusion: Interventions for various ailments that have traditionally ignored population differences have now entered the age of personalized, stratified or precision medicine requiring an individualized approach being adopted as a new standard of care. Factoring in Asian phenotypes is essential for the medical research community and the development of improved clinical practice guidelines across a continuum of disciplines that will ultimately translate to better human health round the world.

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