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Anaesth Intensive Care · Feb 1992
Comparative StudyInter-ethnic differences in postoperative pethidine requirements.
- I T Houghton, C S Aun, T Gin, and J T Lau.
- British Military Hospital, Hong Kong.
- Anaesth Intensive Care. 1992 Feb 1; 20 (1): 52-5.
AbstractA preliminary study of 24 hours' postoperative analgesia using a patient-controlled analgesia technique was undertaken in eight European and fourteen Asian adult patients. All patients had upper abdominal surgery and received weight-related doses of pethidine postoperatively via a Cardiff Palliator. Both groups had a similar degree of analgesia as assessed by visual analogue score but the Asian patients were more sedated in the postoperative period. The Asian patients made 24% fewer demands for analgesia and had a smaller mean (SD) pethidine consumption, 7.62 (2.04) mg.kg-1, compared with the European patients, 9.97 (2.14) mg.kg-1, (P less than 0.05) during the first 24 hours. Further research is necessary to determine whether the smaller requirement for analgesia in Asian patients is a result of pharmacokinetic or pharmacodynamic differences.
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