• Int J Med Sci · Jan 2018

    Biomarkers for Predicting Malignant Pleural Mesothelioma in a Mexican Population.

    • Guadalupe Aguilar-Madrid, Beate Pesch, Emma S Calderón-Aranda, Katarzyna Burek, Carmina Jiménez-Ramírez, Cuauhtémoc Arturo Juárez-Pérez, María Dolores Ochoa-Vázquez, Luis Torre-Bouscoulet, Leonor Concepción Acosta-Saavedra, Isabel Sada-Ovalle, Jorge García-Figueroa, Isabel Alvarado-Cabrero, Patricia Castillo-González, Alejandra Renata Báez-Saldaña, José Rogelio Pérez-Padilla, Juvencio Osnaya-Juárez, Rosa María Rivera-Rosales, Eric Marco García-Bazán, Yolanda Lizbeth Bautista-Aragón, Elimelec Lazcano-Hernandez, Daniel Alejandro Munguía-Canales, Luis Marcelo Argote-Greene, Dirk Taeger, Daniel Gilbert Weber, Swaantje Casjens, Irina Raiko, Thomas Brüning, and Georg Johnen.
    • Research Unit Health at Work, XXI Century National Medical Center (CMNSXXI), Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
    • Int J Med Sci. 2018 Jan 1; 15 (9): 883-891.

    AbstractBackground: Diagnosis of malignant pleural mesothelioma (MPM) remains a challenge, especially when resources in pathology are limited. The study aimed to evaluate cost-effective tumor markers to predict the probability of MPM in plasma samples in order to accelerate the diagnostic workup of the tissue of potential cases. Methods: We conducted a case-control study stratified by gender, which included 75 incident cases with MPM from three Mexican hospitals and 240 controls frequency-matched by age and year of blood drawing. Plasma samples were obtained to determine mesothelin, calretinin, and thrombomodulin using enzyme-linked immunosorbent assays (ELISAs). We estimated the performance of the markers based on the area under the curve (AUC) and predicted the probability of an MPM diagnosis of a potential case based on the marker concentrations. Results: Mesothelin and calretinin, but not thrombomodulin were significant predictors of a diagnosis of MPM with AUCs of 0.90 (95% CI: 0.85-0.95), 0.88 (95% CI: 0.82-0.94), and 0.51 (95% CI: 0.41-0.61) in males, respectively. For MPM diagnosis in men we estimated a true positive rate of 0.79 and a false positive rate of 0.11 for mesothelin. The corresponding figures for calretinin were 0.81 and 0.18, and for both markers combined 0.84 and 0.11, respectively. Conclusions: We developed prediction models based on plasma concentrations of mesothelin and calretinin to estimate the probability of an MPM diagnosis. Both markers showed a good performance and could be used to accelerate the diagnostic workup of tissue samples in Mexico.

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