• S. Afr. Med. J. · Aug 2016

    Case Reports

    Sirolimus-induced lymphoedema.

    • Kagiso G Motse and Mduduzi J Mashabane.
    • School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, South Africa; Division of Nephrology, Chris Hani Baragwanath Academic Hospital, South Africa. kagiso.motse@gmail.com.
    • S. Afr. Med. J. 2016 Aug 2; 106 (9): 886-7.

    AbstractSirolimus is an inhibitor of the mammalian target of rapamycin (mTOR), used as an immunosuppressant for solid-organ transplant recipients and patients with autoimmune disorders. We report a case of lymphoedema, a rare complication of sirolimus, and discuss the mechanism of drug action, the adverse effects and the challenges of treating a kidney transplant recipient with this complication in a resource-limited environment. Lymphoedema is a rare complication of sirolimus, and the mechanisms are not completely understood; however, early recognition can prevent permanent disfiguration. This case highlights the need for early recognition of adverse drug effects and further research into their pathophysiology and management.

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