• Crit Care · Jan 2007

    Comment

    Etomidate, sepsis, and adrenal function: not as bad as we thought?

    • Ryan Kamp and John P Kress.
    • University of Chicago Hospitals, S Maryland Avenue, Chicago, Illinois 60637, USA.
    • Crit Care. 2007 Jan 1;11(3):145.

    AbstractThe choice of induction agent for endotracheal intubation can have significant downstream effects, especially in critically ill patients. In a retrospective study, Ray and McKeown found that the choice of induction agent had no significant effect on use of vasoactive medications, corticosteroids, or mortality. Given the heated debate regarding corticosteroids in septic shock and the role that etomidate may play in leading to adrenal insufficiency, enthusiasm for etomidate as an induction agent should be tempered by its possible, significant side effects in these critically ill patients.

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