• K P Goh, K Chew, A Koh, M Guan, Y S Wong, and C F Sum.
• Department of Medicine, Alexandra Hospital, 378 Alexandra Road, Singapore. kian_peng_goh@alexhosp.com.sg
• Singap Med J. 2009 Oct 1; 50 (10): 997-1003.

IntroductionThe aim of this study was to analyse the association between the ACE ID polymorphism and aerobic capacity in a homogeneous cohort of national Asian rugby players.Methods17 subjects recruited during active training had their maximal oxygen uptake (V0 2 max) and ventilatory threshold (VT) measured during maximal exercise testing. ACE genotyping was performed for all players.ResultsThe likelihood of having a V0 2 max above the 80th percentile of a gender-specific reference range for a normal population was 14.3-fold greater among subjects with the II genotype as compared to the ID genotype (p-value is 0.030). Similarly, subjects with the II genotype were 29.4 times more likely to have a VT above the gender-specific median value compared to the ID genotype (p-value is 0.019). The results suggest that the I allele confers an advantage in aerobic capacity as measured by the V0 2 max and VT.ConclusionIt is likely that the same physiological mechanisms mediated by the ACE gene are responsible for aerobic capacity in both Asians and Caucasians.

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