• Valentina Forni Ogna, Adam Ogna, Philippe Vuistiner, Menno Pruijm, Belen Ponte, Daniel Ackermann, Luca Gabutti, Nima Vakilzadeh, Markus Mohaupt, Pierre-Yves Martin, Idris Guessous, Antoinette Péchère-Bertschi, Fred Paccaud, Murielle Bochud, Michel Burnier, and Swiss Survey on Salt Group.
• Bmc Med. 2015 Feb 27; 13: 4040.

BackgroundUrinary creatinine excretion is used as a marker of completeness of timed urine collections, which are a keystone of several metabolic evaluations in clinical investigations and epidemiological surveys.MethodsWe used data from two independent Swiss cross-sectional population-based studies with standardised 24-hour urinary collection and measured anthropometric variables. Only data from adults of European descent, with estimated glomerular filtration rate (eGFR) ≥60 ml/min/1.73 m2 and reported completeness of the urinary collection were retained. A linear regression model was developed to predict centiles of the 24-hour urinary creatinine excretion in 1,137 participants from the Swiss Survey on Salt and validated in 994 participants from the Swiss Kidney Project on Genes in Hypertension.ResultsThe mean urinary creatinine excretion was 193 ± 41 μmol/kg/24 hours in men and 151 ± 38 μmol/kg/24 hours in women in the Swiss Survey on Salt. The values were inversely correlated with age and body mass index (BMI).ConclusionsWe propose a validated prediction equation for 24-hour urinary creatinine excretion in the general European population, based on readily available variables such as age, sex and BMI, and a few derived normograms to ease its clinical application. This should help healthcare providers to interpret the completeness of a 24-hour urine collection in daily clinical practice and in epidemiological population studies.

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