• Internal medicine · Jun 2022

    Lustrous White Erosions Surrounded by an Erythematous Mucosa: A Novel Endoscopic Finding of Gastric Lesions in Patients with Wilson Disease.

    • Daiki Kitagawa, Masaki Ominami, Koichi Taira, Kojiro Tanoue, Akira Higashimori, Hirotsugu Maruyama, Shigehiro Itani, Yu Nishida, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Yasuaki Nagami, Noriko Kamata, Yuko Kuwae, Toshio Watanabe, Masahiko Ohsawa, Yasuhiro Fujiwara, and F-study Group.
    • Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan.
    • Intern. Med. 2022 Jun 15; 61 (12): 1835-1841.

    AbstractWilson disease is an inherited copper metabolism disorder. We herein report a novel endoscopic finding in three men with Wilson disease. These patients underwent upper endoscopy due to gastrointestinal symptoms or during follow-up. In each case, endoscopy revealed lustrous white erosions surrounded by an erythematous mucosa in the greater curvature of the gastric body. A biopsy of the lesions showed orcein-positive tissue, indicating copper deposition, in the interstitial stroma and fundic glands of the mucosa. All patients had been receiving treatment with zinc acetate. These endoscopic findings might have been related to the cytotoxicity of the accumulated copper and zinc acetate.

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