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Annals of Saudi medicine · Nov 2021
Prognostic impact of human papillomavirus infection on cervical dysplasia, cancer, and patient survival in Saudi Arabia: A 10-year retrospective analysis.
- Fatimah Alhamlan, Dalia Obeid, Hadeel Khayat, Tulbah Asma, Ismail A Al-Badawi, Areej Almutairi, Shihana Almatrrouk, Mohammed Fageeh, Muhammed Bakhrbh, Majed Nassar, and Mohammed Al-Ahdal.
- From the Department of Infection and Immunity, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
- Ann Saudi Med. 2021 Nov 1; 41 (6): 350-360.
BackgroundData on human papillomavirus (HPV) prevalence and survival rates among HPV-infected women are scarce in Saudi Arabia.ObjectiveAssess the prevalence of HPV genotypes in cervical biopsy specimens and its effect on survival over a 10-year timeframe.DesignRetrospective, cross-sectional.SettingsSaudi referral hospital.Patients And MethodsCervical biopsy specimens were collected from women aged 23-95 years old who underwent HPV detection, HPV genotyping, p16INK4a expression measurement using immunohistochemistry. Kaplan-Meier plots were constructed to analyze overall survival rates.Main Outcome MeasuresSurvival rate of HPV-positive cervical cancer patients.Sample Size315 cervical biopsy specimens.ResultsHPV was detected in 96 patients (30.4%): 37.3% had cervical cancer; 14.2% cervical intraepithelial neoplasia (CIN) III, 4.1% CIN II, and 17.0% CIN I. A significant association was found between HPV presence and cervical cancer (χ2=56.78; P<.001). The expression of p16INK4a was a significant predictor of survival: women who had p16INK4a overexpression had poorer survival rates (multivariate Cox regression, hazard ratio, 3.2; 95% CI, 1.1-8.8). In addition, multivariate models with HPV status and cervical cancer diagnosis showed that HPV status was a significant predictor of survival: HPV-positive women had better survival rates than HPV-negative women.ConclusionThese findings suggest that implementing cervical and HPV screening programs may decrease cervical cancer rates and improve survival rates of women in Saudi Arabia.LimitationSingle center and small sample size.Conflict Of InterestNone.
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