• Erdem Koçak, Seyfettin Köklü, Omer Başar, Fatma Meriç Yilmaz, Aydin Ciftçi, Coşkun Kaya, Salih Cesur, Selim Demirci, Erdem Akbal, and Adnan Taş.
• Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey. kocak67@hotmail.com
• Scand. J. Clin. Lab. Invest. 2012 May 1; 72 (3): 192-6.

Background And AimTumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor super family of structurally-related cytokines. The aim of this study was to determine the diagnostic and prognostic role of serum TWEAK concentration in patients with acute pancreatitis.MethodsTwenty four patients with acute pancreatitis and 24 consecutive healthy age- and sex-matched control subjects were included in the study. The serum concentrations of TWEAK were measured at admission and then at remission. The average time between admission and remission was 7-10 days.ResultsAt admission, TWEAK concentration was significantly lower in patients with acute pancreatitis compared to control subjects (p < 0.001). Serum TWEAK concentrations were elevated after the remission period, however the differences were not statistically significant. In addition, serum TWEAK concentration showed a significant, inverse correlation with amylase, lipase, CRP, AST, fibrinogen, LDH and a positive correlation with calcium, albumin and platelet count.ConclusionsPatients with acute pancreatitis have lower serum TWEAK concentration than healthy subjects. These results suggest that serum TWEAK concentration could be a potential biomarker of acute pancreatitis.

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