• J Pediatr Psychol · Jan 2002

    Review

    Methodological issues in outcome studies of at-risk infants.

    • Glen P Aylward.
    • School of Medicine, Southern Illinois University, Springfield, IL 62794-9658, USA. gaylward@siumed.edu
    • J Pediatr Psychol. 2002 Jan 1; 27 (1): 37-45.

    ObjectiveTo identify methodologic problems found in follow-up studies of infants at biologic and environmental risk and provide solutions and recommendations.MethodsThis article is a literature review.ResultsProblems fall into four groupings: (1) conceptualization/design issues, 2) subject population concerns, 3) procedural issues, and 4) measurement/outcome concerns.ConclusionsMain-effect models are not useful; confounding and mediating variables must be identified. In addition, the following are needed: alternative analytic techniques, more precise subject selection and characterization of risk factors, geographically defined samples, broadened scope of outcome measures, and use of epidemiologic techniques.

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