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- M A Dalal, A Schuld, M Haack, M Uhr, P Geisler, I Eisensehr, S Noachtar, and T Pollmächer.
- Max Planck Institute of Psychiatry, Munich, Germany.
- Neurology. 2001 Jun 26; 56 (12): 1749-51.
AbstractDeficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.
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