• Hye Seon Kang, Jae Yeol Kim, Hye Jung Park, Jae-Woo Jung, Hye Sook Choi, Jong Sook Park, Joo Hun Park, Sang Haak Lee, Eun Mi Chun, Yoojung Cho, Eunhee Rhee, Beom Seuk Hwang, and Korean Smoking Cessation Study Group.
• Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
• J. Korean Med. Sci. 2021 Dec 13; 36 (48): e331.

BackgroundThis study aimed to investigate the association between e-cigarette (EC) use and development of acute severe pneumonia in the Korean population using a national database.MethodsWe conducted a retrospective analysis using linkage of data between the Korean National Health and Nutrition Examination Survey (KNHANES) and the National Health Insurance Service (NHIS) administrative claims database. The primary endpoint of this study was development of severe pneumonia requiring hospital admission according to EC use during the study period. The secondary endpoints were in-hospital mortality, intensive care unit (ICU) admission, ventilator care, and days of hospital stay.ResultsThe final analysis included 28,950 individuals, of which 578 (2.0%) were EC users. EC users were younger and more often male than non-EC users. The EC users showed higher level of education and household income and had fewer comorbidities. Severe pneumonia was noted in 37 of 28,372 non-EC users (0.13%), but there were no occurrences of severe pneumonia in EC users. The incidence of pneumonia occurrence was not different between the two groups (P = 1.000).ConclusionsSince e-cigarette or vaping use-associated lung injury (EVALI) is most likely included in acute severe pneumonia occurring within 3 months of EC use, it is considered that there might be no EVALI patients in Korea during the investigation period. A large-scale, prospective study is necessary to evaluate the association between EC use and acute lung injury.© 2021 The Korean Academy of Medical Sciences.

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