• Lamuela L J Calvo, P García Cámara, M Llorente Barrio, O Sierra Gabarda, R Monzón Baez, J M Arbonés Mainar, J Alcedo González, and V Bernal Monterde.
• Gastroenterology Department, Miguel Servet University Hospital, Zaragoza, Spain.
• Eur. J. Clin. Pharmacol. 2021 Dec 1; 77 (12): 1927-1933.

BackgroundProton-pump inhibitors (PPIs) are among the most frequently prescribed drugs, but they are being overprescribed.ObjectiveTo evaluate the applicability of a deprescription algorithm in hospitalized patients with chronic PPI use.MethodsA prospective study including consecutive gastroenterology department hospitalized patients with chronic PPI use. The prescription was reassessed and a deprescribing algorithm was applied. Follow-up was carried out at 4, 12, and 24 weeks.ResultsA total of 513 (44.22%) of 1160 had chronic PPI use; 371 met inclusion criteria and were evaluated: 285 (76.82%) with appropriate prescription and 86 (23.18%) with inappropriate, mainly (52.30%) due to polypharmacy. Seventy-five patients accepted the deprescribing process. Sixty-one (81.33%) maintained deprescription at week 4, 56 (74.66%) at week 12, and 54 (72.00%) at week 24. Eleven of 21 restarted the PPI because of symptoms. No differences were found between the successful deprescription group and the unsuccessful one, regarding sex (p = 0.877), age (p = 0.635), PPI indication (p = 0.663), or deprescription regimen (p = 0.805). No patient had any adverse event attributable to deprescription.ConclusionThere is a high inappropriate indication for PPIs in patients admitted to the gastroenterology department. The application of a patient-centered deprescribing algorithm is a safe and effective strategy to reduce their inappropriate consumption in the medium term.© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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