• Lauren Gilstrap, Ashleigh King, Stephanie Tomlin, and Andrea M Austin.
• Dartmouth-Hitchcock Medical Center, 1 Medical Center Rd, Lebanon, NH 03766. Email: lauren.g.gilstrap@dartmouth.edu.
• Am J Manag Care. 2021 Dec 1; 27 (12): 524-530.

ObjectivesIn the PARADIGM-HF trial, sacubitril/valsartan demonstrated a 20% reduction in mortality and heart failure hospitalization compared with standard angiotensin-converting enzyme inhibitor therapy. Despite this and a class I indication, drug diffusion has been much slower than anticipated. This study aims to examine the variation in early diffusion of sacubitril/valsartan and describe the factors associated with high and low rates of early use.Study DesignAnnual, cross-sectional analyses between January 2016 and December 2018.MethodsWe created a nationally representative cohort of Medicare fee-for-service beneficiaries with heart failure with reduced ejection fraction fully enrolled in parts A, B, and D for at least 1 year between 2016 and 2018. Sacubitril/valsartan use was determined using National Drug Codes. We generated age, sex, and race-adjusted rates of sacubitril/valsartan prescribing by hospital referral region from 2016 to 2018. We also examined the factors associated with high and low rates of early use.ResultsEarly use rates of sacubitril/valsartan were low: 1.9% in 2016, 3.3% in 2017, and 4.0% in 2018. Even after controlling for out-of-pocket co-payments, there was substantial geographic variation in early use, with most early use concentrated in the Northeast and South.ConclusionsThere has been substantial variation in the early diffusion of sacubitril/valsartan. In addition to drug cost, geographic prescribing patterns appear to play a major role in early drug diffusion.

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