• Jangyoun Choi, Jeong Hwa Seo, Jong Yun Choi, Bommie Florence Seo, Ho Kwon, and Sung-No Jung.
• Department of Plastic and Reconstructive Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
• Medicine (Baltimore). 2021 Dec 10; 100 (49): e28002e28002.

RationaleTubular apocrine adenoma (TAA) is a very rare benign neoplasm of the apocrine gland. The typical anatomical locations are mostly hair-bearing areas, where normal apocrine glands are abundant.Patient ConcernsWe report the case of a 40-year-old patient with a tubular apocrine adenoma on a non-hair-bearing area.DiagnosesUltrasonography showed a 0.4-cm-sized hypoechoic nodule in the subcutaneous plane of the left palm at the fourth carpometacarpal joint level.InterventionsSurgical resection was performed and histopathological examination revealed lobules of well-differentiated dilated tubular structures at the dermis level.OutcomesAt 1 year of postoperative follow-up, the patient was completely recovered without signs of recurrence.LessonsDiagnosis of TAA can be misleading due to its unusual location and inconspicuous appearance. Immunohistochemistry for epithelial membrane antigen and gross cystic disease fluid protein-15 is crucial for the proper diagnosis. Complete excision is recommended to prevent recurrence.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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