• Van Leeuwen Ellen, Sibyl Anthierens, Mieke L van Driel, SutterAn DeADepartment of Family Medicine and Primary Health Care, Ghent University, Ghent, Belgium., Evelien van den Branden, and Thierry Christiaens.
• Clinical Pharmacology Unit, Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium.
• Scand J Prim Health Care. 2021 Dec 1; 39 (4): 533542533-542.

BackgroundLong-term antidepressant use, much longer than recommended by guidelines, can harm patients and generate unnecessary costs. Most antidepressants are prescribed by general practitioners (GPs) but it remains unclear why they do not discontinue long-term use.AimTo explore GPs' views and experiences of discontinuing long-term antidepressants, barriers and facilitators of discontinuation and required support.Design And SettingQualitative study in Belgian GPs.Method20 semi-structured face-to-face interviews with GPs. Interviews were analysed thematically.ResultsThe first theme, 'Success stories' describes three strong motivators to discontinue antidepressants: patient health issues, patient requests and a new positive life event. Second, not all GPs consider long-term antidepressant use a 'problem' as they perceive antidepressants as effective and safe. GPs' main concern is the risk of relapse. Third, GPs foresee that discontinuation of antidepressants is not an easy and straightforward process. GPs weigh up whether they have the necessary skills and whether it is worth the effort to start this process.ConclusionDiscontinuation of long-term antidepressants is a difficult and uncertain process for GPs, especially in the absence of a facilitating life-event or patient demand. The absence of a compelling need for discontinuation and fear of relapse of symptoms in a stable patient are important barriers for GPs when considering discontinuation. In order to increase GPs' motivation to discontinue long-term antidepressants, more emphasis on the futility of the actual effect and on potential harms related to long-term use is needed.KEY POINTSCurrent awareness:Long-term antidepressant use, much longer than recommended by guidelines, can harm patients and generate unnecessary costs.Main statements: • Discontinuation of long-term antidepressants is a difficult and uncertain process for GPs. • More emphasis on the futility of the actual effect of antidepressants and on potential harms related to long-term use is needed.

11 keywords...

hide…