• Raquel Lucas, Maria Brandão, Vanessa Gorito, and Makram Talih.
• EPIUnit (Epidemiology Research Unit), ITR (Laboratory for Integrative and Translational Research in Population Health), Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
• Eur J Pain. 2022 Mar 1; 26 (3): 695-708.

BackgroundWe evaluated different pain profiles as prospective predictors of multisite pain in 13-year-old adolescents (1300 girls and 1457 boys) enrolled in Generation XXI, a birth cohort study in Portugal.MethodsPain history was queried using the Luebeck Pain Questionnaire through parent proxy- (ages 7 and 10) and adolescent (age 13) self-reports. We estimated the risk of multisite pain (2 or more pain sites) at age 13, according to previous pain experiences, including accumulation and timing. We defined five profiles that combined adverse features at ages 7 and 10 (recurrence, multisite, frequency, duration, intensity, triggers, activity restrictions, passive coping, and family history) and estimated their relative risks (RR) and likelihood ratios (LR) for adolescent multisite pain.ResultsAt age 13, 39.2% of girls and 27.2% of boys reported multisite pain in the previous three months. The risk was higher among girls with multisite and recurrent pain at ages 7 and 10 than in girls without those adverse features, especially if psychosocial triggers were also present (RR 1.87; 95% confidence interval 1.36, 2.36 and LR 3.49; 1.53, 7.96). Boys with recurrent pain of higher frequency and causing activity restrictions at ages 7 and 10 had a higher risk of multisite pain at 13 (RR 2.05; 1.03, 3.05 and LR 3.06; 1.12, 8.39). Earlier adverse experiences were more predictive of future pain in girls than in boys.ConclusionsDifferent profiles were useful to rule in future multisite pain in boys and girls. This provides clues for early stratification of chronic pain risk.SignificanceWe identified sex-specific pain features that can be collected by practitioners in the first decade of life to improve the stratification of children in terms of their future risk of a maladaptive pain experience in adolescence. Using a prospective population-based cohort design, we show that early multisite pain and psychosocial triggers are relevant predictors of future multisite pain in girls, whereas repeated reports of high-frequency pain leading to activity restrictions are predictive of adolescent multisite pain in boys.© 2021 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation - EFIC ®.

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