• Lin Fang, Shushan Wang, Leiming Cao, and Kun Yao.
• Department of Clinical Psychology, The Affiliated Wuxi Mental Health Center with Nanjing Medical University, Wuxi, Jiangsu 214151, China.
• Medicine (Baltimore). 2021 Dec 10; 100 (49): e28140e28140.

RationaleDrug-induced liver injury (DILI) is the leading cause of acute liver injury (ALI), market withdrawal of a drug, and rejection of applications for marketing licenses. The incidence of DILI is very low, with a value between 1 and 19 per 100,000 patient years. All antidepressants may induce DILI even at low therapeutic doses. In this report, we present a case of ALI after venlafaxine administration.Patient ConcernsA 27-year-old Chinese Han woman was admitted for depression. Several serum liver function indices in this patient were abnormal after antidepressant treatment. The Roussel Uclaf Causality Assessment Method (RUCAM) causality assessment score was 8, and the R value was 31.18.DiagnosesThe patient was diagnosed with hepatocellular ALI, which was derived from venlafaxine-related adverse events.InterventionsFirst, all medications were stopped to block the progression of DILI. Then, a hepatoprotective strategy and proper psychological treatment were performed to recover the impaired hepatic function.OutcomesLiver function was fully recovered as indicated by liver function indices and ultrasound imaging.LessonsThe possibility of DILI should not be overlooked during the long-term use of antipsychotic drugs. In response, regular liver function monitoring should be performed in a timely manner to avoid missing diagnoses and delayed treatment. Furthermore, the necessary medical treatment needs to be conducted after the occurrence of ALI.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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