• Mi Sun, Xian Jin, Mingxiao Zang, Weijia Jiang, Chunxiao Zhao, Jieyu Bi, Huijuan Yu, and Qiwen Tan.
• Department of Acupuncture and Moxibustion, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
• Medicine (Baltimore). 2021 Dec 10; 100 (49): e28174.

BackgroundCoronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease which making people difficult to breathe and often accompanied with headache. Acupuncture have been proved the therapeutic effect on headache, but there has been no high-quality evidence on acupuncture for the headache in COVID-19. This study is designed to evaluate the effectiveness and safety of acupuncture for headache in COVID-19.MethodsRandomized controlled trials from December 2019 to July 2021 will be included without restrictions on language or publication date. PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Databases, China National Knowledge Infrastructure, Wanfang database, and VIP database will be searched. Two researchers will independently select studies, extract data and evaluate study quality. Cochrane risk of bias tool for randomized trials will be used to assess the risk of bias of included studies. Statistical analyses will be performed using the Review Manager V.5.3 and stata 14.0.Ethics And DisseminationThis study will not involve personal information. Ethical approval will not be required. We will publish the results in a peer-reviewed journal.Prospero Trial Registration NumberCRD42021270722.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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