• Guangjun Xu, Jiaoni Zheng, Jianghui Cai, Jing Zhang, Jue Liu, and Shu Tang.
• Department of Ophthalmology, Chongqing University Center Hospital, Chongqing Emergency Medical Center, Chongqing Fourth People's Hospital, Chongqing, China.
• Medicine (Baltimore). 2021 Dec 10; 100 (49): e28189.

BackgroundCorticosteroids have been one of the most frequently used therapeutics in ophthalmology over the past decades, known for their potent anti-inflammatory and immunosuppressive actions. Intraocular pressure elevation has proven to be a significant ocular side effect that could accompany steroid use. However, the information on ocular-hypertensive corticosteroid response is scant in children. We aim to systematically describe the corticosteroid-induced intraocular pressure elevation in the pediatric age group.MethodsPubMed, Embase, Web of Science, Cochrane Library, Latin American and Caribbean Health Sciences Literature, and the Chinese Biomedical Literature database will be searched for potential articles from database inception to April 29, 2021. No language restrictions will be applied. Studies involving patients less than 18 years old receiving corticosteroids will be included. We will screen abstracts for relevance, extract data, and assess the risk of bias in duplicate. We will rate the certainty of evidence using the Grading of Recommendations Assessment Development and Evaluation approach. The primary outcome will be the intraocular pressure in pediatric patients group. We will provide a narrative synthesis of the findings.ResultsThe systematic review will provide high-quality evidence to assess the relationship between dosage, frequency, route of administration, and duration of corticosteroid on intraocular pressure in children.ConclusionThe systematic review will provide evidence to assess the safety of corticosteroid for ocular diseases in pediatric population.Prospero Registration NumberCRD42021252298.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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