• Nazish Butt, AnoshiaDr. Anoshia, MBBS, FCPS. Consultant Gastroenterologist, Department of Gastroenterology, Jinnah Postgraduate Medical Center, Karachi, Pakistan., Muhammad Ali Khan, and Ali Akbar.
• Dr. Nazish Butt, MBBS, FCPS. Assistant Professor, Head Department of Gastroenterology, Department of Gastroenterology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
• Pak J Med Sci. 2021 Nov 1; 37 (7): 2014-2019.

ObjectiveTo assess the effectiveness of Sofosbuvir (SOF) and Daclatasvir (DCV) in patients with chronic hepatitis C (CHC), compensated cirrhosis (CC) and decompensated cirrhosis (DCLD) either treatment naïve or experienced.MethodsThis was a prospective, observational study, conducted from January 2017 to December 2018 at Jinnah Postgraduate Medical Centre, Karachi. All patients above 12 years of age with detectable HCV RNA PCR were included. Patients were divided into three groups: CHC, CC and DCLD. SOF and DCV for 12 or 24 weeks were given. Ribavirin (RBV) was given to treatment experienced and cirrhotic patients. Primary outcome was End of Treatment Response (ETR) and secondary outcome was Sustained Virological Response (SVR) at post treatment week 12 or 24.ResultsTotal 300 patients with mean age of 40.49 ± 13.86 were enrolled. Majority were females 174 (58%). CHC were 200 (66.6%) while cirrhotic were 100 (33.4%). Treatment naïve patients were 267 (89%) and 33 (11%) patients were experienced. Most common genotype was 3 (83%). ETR was achieved in 292 (97.33%) and SVR in 265 (88.33%) patients respectively.ConclusionSOF plus DCV with or without RBV is a highly effective treatment for chronic HCV and is still used in many centers of Pakistan. This regimen has excellent results for GT-3. The outcomes are mainly influenced by the presence or absence of cirrhosis.Copyright: © Pakistan Journal of Medical Sciences.

4 keywords...

hide…